Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Desirable L-asparaginases for treating cancer and current research trends

13 Mar 2024

Abstract excerpt

Amino acid depletion therapy is a promising approach for cancer treatment. It exploits the differences in the metabolic processes between healthy and cancerous cells. Certain microbial enzymes induce cancer cell apoptosis by removing essential amino acids. L-asparaginase is an enzyme approved by the FDA for the treatment of acute lymphoblastic leukemia. The enzymes currently employed in clinics come from two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Biochemical and Molecular Research
Share to Cancer Research and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38591038
DOI: 10.3389/fmicb.2024.1269282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Desirable L-asparaginases for treating cancer and current research trendsPMID 38591038Read ↗

Comparative immunogenicity and structural analysis of epitopes of different bacterial L-asparaginasesSemantic proximity Read ↗

Structural and biochemical properties of L‐asparaginaseSemantic proximity Read ↗

Possible mechanism of metabolic and drug resistance with L-asparaginase therapy in childhood leukaemiaSemantic proximity Read ↗

Structural and functional diversity of asparaginases: Overview and recommendations for a revised nomenclatureSemantic proximity Read ↗

Nonclinical Evaluation of Single-Mutant E. coli Asparaginases Obtained by Double-Mutant Deconvolution: Improving Toxicological, Immune and Inflammatory Responses.Semantic proximity Read ↗

Structure, Substrate Complexation and Reaction Mechanism of Bacterial AsparaginasesSemantic proximity Read ↗

Optimization and characterization of antileukemic L-asparaginase produced by Fusarium solani endophyteSemantic proximity Read ↗

Metagenomic discovery and functional validation of L-asparaginases with anti-leukemic effect from the Caspian SeaSemantic proximity Read ↗

Mutations in asparaginase II from E. coli and implications for inactivation and PEGylation.Semantic proximity Read ↗

Structural and functional role of Gly281 in L-asparaginase from Erwinia carotovora.Semantic proximity Read ↗

Asparagine: A Metabolite to Be Targeted in CancersSemantic proximity Read ↗

Metagenomic discovery and functional validation of L-asparaginases with anti-leukemic effect from the Caspian SeaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.