Article

Metabolic Profile Of Leukemia Cells Influences Treatment Efficacy Of L‑Asparaginase

2019-11-20

Abstract excerpt

<h4>Background: </h4> Effectiveness of L-asparaginase administration in acute lymphoblastic leukemia treatment is mirrored in overall outcome of patients. Generally, leukemia patients differ in their sensitivity to L-asparaginase; however, the mechanism underlying their inter-individual differences is still not fully understood. We have previously shown that L-asparaginase rewires the biosynthetic and bioenergetic...

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Literature Corpus work: c2c2931e-80a4-5344-b162-848a250cbf84
DOI: 10.21203/rs.2.17519/v1

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