Article
Characterization of the impact of the MYBBP1A gene and rs3809849 on asparaginase sensitivity and cellular functions.
Pharmacogenomics - 1 May 2022
Abaji Rachid, Roux Vincent, Yssaad Ismahène Reguieg, Kalegari Paloma, Gagné Vincent, Gioia Romain, Ferbeyre Gerardo, Beauséjour Christian, Krajinovic Maja
Abstract excerpt
Aims: To investigate the role of MYBBP1A gene and rs3809849 in pancreatic cancer (PANC1) and lymphoblastic leukemia (NALM6) cell lines and their response to asparaginase treatment. Materials & methods: The authors applied CRISPR-Cas9 to produce MYBBP1A knock-out (KO) and rs3809849 knock-in (KI) cell lines. The authors also interrogated rs3809849's impact on PANC1 cells through allele-specific overexpression....
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