Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Asparagine: A Metabolite to Be Targeted in Cancers

19 Jun 2021

Abstract excerpt

Amino acids play central roles in cancer progression beyond their function as building blocks for protein synthesis. Thus, targeting amino acid acquisition and utilization has been proved to be therapeutically beneficial in various pre-clinical models. In this regard, depletion of circulating asparagine, a nonessential amino acid, by L-asparaginase has been used in treating pediatric acute lymphoblastic leukemia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Molecular Research
Share to Epigenetics and DNA Methylation
Share to Folate and B Vitamins Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34205460
DOI: 10.3390/metabo11060402

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Asparagine: A Metabolite to Be Targeted in CancersPMID 34205460Read ↗

Targeting Asparagine Metabolism in Solid TumorsSemantic proximity Read ↗

Update on the Use of L-Asparaginase in Infants and Adolescent Patients with Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

SLC1A3 contributes to L‐asparaginase resistance in solid tumorsSemantic proximity Read ↗

A clinically attainable dose of L‐asparaginase targets glutamine addiction in lymphoid cell linesSemantic proximity Read ↗

Metabolic Profile Of Leukemia Cells Influences Treatment Efficacy Of L‑AsparaginaseSemantic proximity Read ↗

L-Asparaginase treatment induces reversible immunoregulatory and immunosuppressive effects in non-malignant B cells in a model of T-cell dependent B cell activationSemantic proximity Read ↗

Possible mechanism of metabolic and drug resistance with L-asparaginase therapy in childhood leukaemiaSemantic proximity Read ↗

Amino acid metabolic reprogramming in the tumor microenvironment and its implication for cancer therapySemantic proximity Read ↗

Desirable L-asparaginases for treating cancer and current research trendsSemantic proximity Read ↗

Drivers of de novo Serine/Glycine synthesis in acute leukemia.Semantic proximity Read ↗

PTEN/PI3K/Akt pathway alters sensitivity of T-cell acute lymphoblastic leukemia to l-asparaginaseSemantic proximity Read ↗

Targeting Amino Acid Metabolic Vulnerabilities in Myeloid MalignanciesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.