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Targeting Asparagine Metabolism in Solid Tumors

3 Jan 2025

Abstract excerpt

Reprogramming of energy metabolism to support cellular growth is a "hallmark" of cancer, allowing cancer cells to balance the catabolic demands with the anabolic needs of producing the nucleotides, amino acids, and lipids necessary for tumor growth. Metabolic alterations, or "addiction", are promising therapeutic targets and the focus of many drug discovery programs. Asparagine metabolism has gained much...

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PMID: 39796613
DOI: 10.3390/nu17010179

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