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The association between the <i>HLA-DRB1</i> shared epitope alleles and the risk of rheumatoid arthritis is influenced by massive gene-gene interactions

2017-11-17

Abstract excerpt

In anti-citrullinated protein antibody positive rheumatoid arthritis (ACPA-positive RA), a particular subset of HLA-DRB1 alleles, called shared epitope alleles (SE), is the highest genetic risk factor. Here, we aimed to investigate whether gene-gene interactions influence this HLA-DRB1 related major disease risk; specifically, we set out to test if non-HLA SNPs, conferring low diseases risk on their own, can mod...

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Literature Corpus work
8d4e0e70-0ae5-50e0-959d-19755bcd4064
DOI
10.1101/221416
Open publication

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The association between the <i>HLA-DRB1</i> shared epitope alleles and the risk of rheumatoid arthritis is influenced by massive gene-gene interactionsDOI 10.1101/221416
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