Article
Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis.
Arthritis and rheumatism - 1 Apr 2009
van der Woude Diane, Houwing-Duistermaat Jeanine J, Toes René E M, Huizinga Tom W J, Thomson Wendy, Worthington Jane, van der Helm-van Mil Annette H M, de Vries René R P
Abstract excerpt
OBJECTIVE: The majority of genetic risk factors for rheumatoid arthritis (RA) are associated with anti-citrullinated protein antibody (ACPA)-positive RA, while far fewer genetic risk factors have been identified for ACPA-negative RA. This study was undertaken to quantify the contribution of genetic risk factors in general, and of the predisposing HLA-DRB1 shared epitope (SE) alleles in particular, to the...
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