Article
Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region.
Arthritis and rheumatism - 1 Jan 2009
Ding Bo, Padyukov Leonid, Lundström Emeli, Seielstad Mark, Plenge Robert M, Oksenberg Jorge R, Gregersen Peter K, Alfredsson Lars, Klareskog Lars
Abstract excerpt
OBJECTIVE: To identify additional variants in the major histocompatibility complex (MHC) region that independently contribute to risk in 2 disease subsets of rheumatoid arthritis (RA) defined according to the presence or absence of antibodies to citrullinated protein antigens (ACPAs). METHODS: In a multistep analytical strategy using unmatched as well as matched analyses to adjust for HLA-DRB1 genotype, we...
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