Article
Genetic landscape of interactive effects of HLA-DRB1 alleles on susceptibility to ACPA(+) rheumatoid arthritis and ACPA levels in Japanese population.
Journal of medical genetics - 1 Dec 2017
Terao Chikashi, Okada Yukinori, Ikari Katsunori, Kochi Yuta, Suzuki Akari, Ohmura Koichiro, Matsuo Keitaro, Taniguchi Atsuo, Kubo Michiaki, Raychaudhuri Soumya, Yamamoto Kazuhiko, Yamanaka Hisashi, Kamatani Yoichiro, Mimori Tsuneyo, Matsuda Fumihiko
Abstract excerpt
BACKGROUND: HLA-DRB1 is the strongest susceptibility gene to rheumatoid arthritis (RA). HLA-DRB1 alleles showed significant non-additive and interactive effects on susceptibility to RA in the European population, but these effects on RA susceptibility should vary between populations due to the difference in allelic distribution. Furthermore, non-additive or interactive effects on the phenotypes of RA are not...
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