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Article

HLA-DR risk variants in rheumatoid arthritis: what we know and still do not know.

RMD open - 20 May 2026

Yap Chuan Fu, Viatte Sebastien

Abstract excerpt

Rheumatoid arthritis (RA) susceptibility is strongly influenced by genetic variations within the major histocompatibility complex, with HLA-DRB1 risk alleles representing the largest contributors to heritability, particularly in seropositive (anti-citrullinated protein antibody positive) disease. The shared epitope (SE) hypothesis, first proposed more than three decades ago, explained the clustering of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42161413
DOI: 10.1136/rmdopen-2025-006045
PMCID: PMC13202002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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