Article
The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis.
Arthritis and rheumatism - 1 Apr 2006
van der Helm-van Mil Annette H M, Verpoort Kirsten N, Breedveld Ferdinand C, Huizinga Tom W J, Toes René E M, de Vries René R P
Abstract excerpt
OBJECTIVE: The shared epitope (SE)-containing HLA-DRB1 alleles represent the most significant genetic risk factor for rheumatoid arthritis (RA). Recent studies indicate that the SE alleles are associated with only RA that is characterized by the presence of anti-cyclic citrullinated peptide (anti-CCP) antibodies, and not with anti-CCP-negative disease. In this study we investigated whether the SE alleles...
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