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Article

Systematic approach demonstrates enrichment of multiple interactions between non-HLA risk variants and HLA-DRB1 risk alleles in rheumatoid arthritis.

Annals of the rheumatic diseases - 1 Oct 2018

Diaz-Gallo Lina-Marcela, Ramsköld Daniel, Shchetynsky Klementy, Folkersen Lasse, Chemin Karine, Brynedal Boel, Uebe Steffen, Okada Yukinori, Alfredsson Lars, Klareskog Lars, Padyukov Leonid

Abstract excerpt

OBJECTIVE: In anti-citrullinated protein antibody positive rheumatoid arthritis (ACPA-positive RA), a particular subset of HLA-DRB1 alleles, called shared epitope (SE) alleles, is a highly influential genetic risk factor. Here, we investigated whether non-HLA single nucleotide polymorphisms (SNP), conferring low disease risk on their own, interact with SE alleles more frequently than expected by chance and if...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

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Share to HLA-DRB1 Chains

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Identifiers

PMID: 29967194
DOI: 10.1136/annrheumdis-2018-213412
PMCID: PMC6161669

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