Back to search

Article

Expression levels of <i>HLA-DRB</i> and <i>HLA-DQ</i> are associated with MHC Class II haplotypes in healthy individuals and rheumatoid arthritis patients

2021-01-06

Abstract excerpt

HLA-DRB1 alleles have been associated with several autoimmune diseases. In anti-citrullinated protein antibody positive rheumatoid arthritis (ACPA-positive RA), HLA-DRB1 shared epitope (SE) alleles are the major genetic risk factors. In order to investigate whether expression of different alleles of major histocompatibility complex (MHC) Class II genes influence functions of immune cells, we investigated transcrip...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c4dea906-eed5-5bef-a09f-da93ab3c7119
DOI
10.1101/2021.01.06.20249032
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Expression levels of <i>HLA-DRB</i> and <i>HLA-DQ</i> are associated with MHC Class II haplotypes in healthy individuals and rheumatoid arthritis patientsDOI 10.1101/2021.01.06.20249032
Haplotype-Specific Expression Analysis of MHC Class II Genes in Healthy Individuals and Rheumatoid Arthritis Patients.Semantic proximity
HLA-DR risk variants in rheumatoid arthritis: what we know and still do not know.Semantic proximity
Antigen Presentation-Independent Reciprocal Immune Modulation by <i>HLA-DRB1</i> Allelic Epitopes that Associate with Autoimmune Disease Risk or ProtectionSemantic proximity
The influence of HLA genetic variation on plasma protein expressionSemantic proximity
Complete sequences of six Major Histocompatibility Complex haplotypes, including all the major <i>MHC class II</i> structuresSemantic proximity
Immunogenetics of HLA-B: SNP, allele, and haplotype diversity in populations from different continents and ancestry backgrounds.Semantic proximity
Immunophenotyping of rheumatoid arthritis reveals a linkage between HLA-DRB1 genotype, CXCR4 expression on memory CD4(+) T cells, and disease activity.Semantic proximity
Biology of HLA class I associated inflammatory diseases.Semantic proximity
Capturing Differential Allele-Level Expression and Genotypes of All Classical HLA Loci and Haplotypes by a New Capture RNA-Seq Method.Semantic proximity
HLA RNA Sequencing With Unique Molecular Identifiers Reveals High Allele-Specific Variability in mRNA Expression.Semantic proximity
The association between the <i>HLA-DRB1</i> shared epitope alleles and the risk of rheumatoid arthritis is influenced by massive gene-gene interactionsSemantic proximity
Autoantigen-specific CD8+ T-cell signature in Rheumatoid ArthritisSemantic proximity
Select a neighboring publication to make it the new centre.