Interaction analysis between HLA-DRB1 shared epitope alleles and MHC class II transactivator CIITA gene with regard to risk of rheumatoid arthritis.

doi:10.1371/journal.pone.0032861

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Article

Interaction analysis between HLA-DRB1 shared epitope alleles and MHC class II transactivator CIITA gene with regard to risk of rheumatoid arthritis.

PloS one - 1 Jan 2012

Ronninger Marcus, Seddighzadeh Maria, Eike Morten Christoph, Plant Darren, Daha Nina A, Skinningsrud Beate, Worthington Jane, Kvien Tore K, Toes Rene E M, Lie Benedicte A, Alfredsson Lars, Padyukov Leonid

Abstract excerpt

HLA-DRB1 shared epitope (SE) alleles are the strongest genetic determinants for autoantibody positive rheumatoid arthritis (RA). One of the key regulators in expression of HLA class II receptors is MHC class II transactivator (CIITA). A variant of the CIITA gene has been found to associate with inflammatory diseases.We wanted to explore whether the risk variant rs3087456 in the CIITA gene interacts with the...

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PMID: 22461888
DOI: 10.1371/journal.pone.0032861
PMCID: PMC3312880

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CIITA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Interaction analysis between HLA-DRB1 shared epitope alleles and MHC class II transactivator CIITA gene with regard to risk of rheumatoid arthritis.PMID 22461888Read ↗

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