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Article

Interaction of HLA-DRB109:01 and 04:05 with smoking suggests distinctive mechanisms of rheumatoid arthritis susceptibility beyond the shared epitope.

The Journal of rheumatology - 1 Jul 2013

Bang So-Young, Lee Hye-Soon, Lee Kyung Wha, Bae Sang-Cheol

Abstract excerpt

OBJECTIVE: Although HLA-DRB1 shared epitope (SE) alleles and HLA-DRB1*09:01 have repeatedly been shown to be associated with susceptibility to rheumatoid arthritis (RA), the effect of each allele on levels of anticyclic citrullinated peptide autoantibodies (anti-CCP) and interaction with cigarette smoking in RA remains to be fully defined. We investigated whether HLA-DRB1 risk alleles influence anti-CCP levels...

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Share to Arthritis, Rheumatoid
Share to Autoantibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes

Share to Gene-Environment Interaction

Share to HLA-DRB1 Chains

Share to Peptides, Cyclic

Share to Rheumatoid Factor

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Source

Identifiers

PMID: 23637323
DOI: 10.3899/jrheum.121280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Interaction of HLA-DRB1*09:01 and *04:05 with smoking suggests distinctive mechanisms of rheumatoid arthritis susceptibility beyond the shared epitope.PMID 23637323Read ↗

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