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Metabolic priming of GD2 <i>TRAC</i> -CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence

2024-02-02

Abstract excerpt

<h4>ABSTRACT</h4> Manufacturing Chimeric Antigen Receptor (CAR) T cell therapies is complex, with limited understanding of how media composition impact T-cell phenotypes. CRISPR/Cas9 ribonucleoproteins can precisely insert a CAR sequence while disrupting the endogenous T cell receptor alpha constant ( TRAC ) gene resulting in TRAC -CAR T cells with an enriched stem cell memory T-cell population, a process that...

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Literature Corpus work
8d4c8c98-255a-572b-ab8e-07b384d927df
DOI
10.1101/2024.01.31.575774
Open publication

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Metabolic priming of GD2 <i>TRAC</i> -CAR T cells during manufacturing promotes memory phenotypes while enhancing persistenceDOI 10.1101/2024.01.31.575774
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