Article

Palbociclib and Rapamycin pretreatment boosted the persistence and functionality of CAR-T cells in solid tumors through metabolic reprogramming

2026-02-16

Abstract excerpt

<title>Abstract</title> <bold>Background:</bold> Chimeric antigen receptor T cell (CAR-T) therapy has shown remarkable success in treating hematologic malignancies; however, its efficacy against solid tumors remains limited due to the immunosuppressive tumor microenvironment. Enhancing CAR-T cell persistence and function through the use of culture media additives offers a potential strategy to overcome thes...

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Literature Corpus work: 38b076fc-c18d-567c-bbf3-ea88479f9ef1
DOI: 10.21203/rs.3.rs-8788062/v1

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