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Breaking the Barriers in CAR-T Cell Therapy: Addressing Toxicity, Tumor Microenvironment Suppression, Persistence Challenges, and Trafficking Deficits

2026-02-13

Abstract excerpt

Chimeric antigen receptor (CAR)-T cell therapy has transformed the management of hematologic malignancies but faces obstacles, including severe treatment-related toxicities, highly suppressive tumor microenvironment (TME), inadequate long-term persistence, and poor trafficking/infiltration into solid tumor. This review summarizes recent genetic engineering strategies designed to overcome these barriers and to impr...

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Literature Corpus work
ac1cd945-bb25-5a75-b558-829b616b6558
DOI
10.20944/preprints202602.1124.v1
Open publication

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Breaking the Barriers in CAR-T Cell Therapy: Addressing Toxicity, Tumor Microenvironment Suppression, Persistence Challenges, and Trafficking DeficitsDOI 10.20944/preprints202602.1124.v1
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