Article

Programmable microparticles rewire CAR signaling to enable super-physiological expansion of human T cells <i>in vitro</i>

2025-07-22

Abstract excerpt

T cell proliferative capacity and persistence critically determine the therapeutic success of chimeric antigen receptor (CAR) T cells. However, it remains unknown if and how human CAR-T cells can be externally programmed to reach maximal proliferative capacity. Here, we use programmable PLGA microparticles functionalized with CAR-antigens and CD28-costimulatory antibodies (CAREp) to repeatedly stimulate human CD8...

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Literature Corpus work: 53820b94-1f91-5aa9-bc17-d49e0119b82a
DOI: 10.1101/2025.07.17.665438

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