Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression

1 Sept 2022

Abstract excerpt

Background Chimeric antigen receptor (CAR) T cells have demonstrated high clinical response rates against hematological malignancies (e.g., CD19+ cancers) but have shown limited activity in patients with solid tumors. Recent work showed that precise insertion of a CAR at a defined locus improves treatment outcomes in the context of a CD19 CAR; however, it is unclear if such a strategy could also affect outcomes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Neuroblastoma Research and Treatments
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36382633
DOI: 10.1136/jitc-2021-004446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regressionPMID 36382633Read ↗

Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regressionSemantic proximity Read ↗

Generating universal anti-CD19 CAR T cells with a defined memory phenotype by CRISPR/Cas9 editing and safety evaluation of the transcriptome.Semantic proximity Read ↗

Non-viral expression of chimeric antigen receptors with multiplex gene editing in primary T cellsSemantic proximity Read ↗

Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturingSemantic proximity Read ↗

Long Terminal Repeat CRISPR-CAR-Coupled “Universal” T Cells Mediate Potent Anti-leukemic EffectsSemantic proximity Read ↗

Efficient Gene Editing of CART Cells with CRISPR-Cas12a for Enhanced Antitumor EfficacySemantic proximity Read ↗

Fast, efficient and virus-free generation of <i>TRAC</i> -replaced CAR T cellsSemantic proximity Read ↗

Metabolic priming of GD2 TRAC-CAR T cells during manufacturing promotes memory phenotypes while enhancing persistenceSemantic proximity Read ↗

Are entirely virus-free CAR T cells as good as lentiviral transduced universal cells?Semantic proximity Read ↗

Non-viral precision T cell receptor replacement for personalized cell therapy.Semantic proximity Read ↗

Efficient nonviral integration of large transgenes into human T cells using Cas9-CLIPTSemantic proximity Read ↗

Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.