Article

Inosine Induces Stemness Features in CAR T cells and Enhances Potency

2023-04-25

Abstract excerpt

Adenosine (Ado) mediates immune suppression in the tumor microenvironment and exhausted CD8 + CAR T cells mediate Ado-induced immunosuppression through CD39/73-dependent Ado production. Knockout of CD39, CD73 or A2aR had modest effects on exhausted CAR T cells, whereas overexpression of Ado deaminase (ADA), which metabolizes Ado to inosine (INO), induced stemness features and potently enhanced functionality. Simi...

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Identifiers and source

Literature Corpus work: a19a154d-ec01-5b50-8a43-f2c982d63d8b
DOI: 10.1101/2023.04.21.537859

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