Article

Directing fratricide within T cell products using an anti-uPAR chimeric antigen receptor to drive the production of potent therapeutic cells

2025-10-25

Abstract excerpt

Cell therapy manufacturing of primary T cells often results in heterogeneous cell populations within a final product, with many cells lacking desired of receptor expression or those that have exhausted or other dysfunctional phenotypes. Here, we design a novel cell-intrinsic strategy to genetically reprogram primary human T cells to autonomously detect and eliminate dysfunctional cells. This integrated detection a...

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Literature Corpus work: 9adf39c4-8af6-5c32-863c-6aa347a25267
DOI: 10.1101/2025.10.24.684419

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