Article

Metabolic armouring of CAR and TCR T cells

2024-03-28

Abstract excerpt

<title>Abstract</title> <p>Cancer immune therapy with engineered immune cells is standard of care in certain hematologic malignancies. However, solid tumor outcomes in clinical trials are lagging significantly behind. Engineered T cells face a myriad of challenges within the tumor microenvironment, one of which is competition for metabolites and a carbon source for adenosine triphosphate generation. Glucose is th...

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Literature Corpus work: 3c800552-6dd8-511a-8653-88dec9bc7683
DOI: 10.21203/rs.3.rs-4020589/v1

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