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Fueling CARs: metabolic strategies to enhance CAR T-cell therapy

10 Jul 2024

Abstract excerpt

CAR T cells are widely applied for relapsed hematological cancer patients. With six approved cell therapies, for Multiple Myeloma and other B-cell malignancies, new insights emerge. Profound evidence shows that patients who fail CAR T-cell therapy have, aside from antigen escape, a more glycolytic and weakened metabolism in their CAR T cells, accompanied by a short lifespan. Recent advances show that CAR T cells...

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PMID: 38987856
DOI: 10.1186/s40164-024-00535-1

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