Article

Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cell therapy

2022-10-31

Abstract excerpt

<h4>ABSTRACT</h4> Adoptive cell transfer (ACT) therapy with IL-17 producing human T cells elicits potent antitumor activity in preclinical models. However, further refinement of this novel approach is needed to position it for clinical application. While activation signal strength differentially regulates IL-17 production by human CD4 + T cells, the degree to which TCR and co-stimulation signal strength impacts...

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Literature Corpus work: 5f41e6d4-ea78-5145-95a0-78e9d37ab279
DOI: 10.1101/2022.10.28.514057

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