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Article

Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Jun 2021

Malaiya Sonia, Cortes-Gutierrez Marcia, Herb Brian R, Coffey Sydney R, Legg Samuel R W, Cantle Jeffrey P, Colantuoni Carlo, Carroll Jeffrey B, Ament Seth A

Abstract excerpt

Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by a trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Cell death in HD occurs primarily in striatal medium spiny neurons (MSNs), but the involvement of specific MSN subtypes and of other striatal cell types remains poorly understood. To gain insight into cell type-specific disease processes, we studied the nuclear...

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Identifiers

PMID: 34011527
DOI: 10.1523/JNEUROSCI.2074-20.2021
PMCID: PMC8221598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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