Article

Single-cell atlas of progressive supranuclear palsy reveals a distinct hybrid glial cell population

2021-04-12

Abstract excerpt

Progressive supranuclear palsy (PSP) is a neurodegenerative disorder whose molecular complexity at a single cell level has not been evaluated. Here we analyzed 45,559 high quality nuclei from the subthalamic nucleus and associated basal ganglia regions from post-mortem human PSP brains with varying degrees of tau pathology compared to controls ( n =3 per group). We identified novel astrocyte-oligodendrocyte hybri...

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Literature Corpus work: 80e3bfa0-60aa-5c73-8a9b-e0ac4d8ffb1b
DOI: 10.1101/2021.04.11.439393

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