Article

Single-nucleus RNA-seq reveals dysregulation of striatal cell identity due to Huntington’s disease mutations

2020-07-09

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a trinucleotide expansion in exon 1 of the huntingtin ( Htt ) gene. Cell death in HD occurs primarily in striatal medium spiny neurons (MSNs), but the involvement of specific MSN subtypes and of other striatal cell types remains poorly understood. To gain insight into cell type-specific disease processes, w...

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Literature Corpus work: d5eb28e5-933f-51e2-a25b-e88e4cda145b
DOI: 10.1101/2020.07.08.192880

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