Article

Multi-transcriptomic analysis points to early organelle dysfunction in human astrocytes in Alzheimer’s disease

2021-03-01

Abstract excerpt

Recent single-nucleus RNA sequencing of astrocytes in postmortem Alzheimer’s disease (AD) samples is limited by the low number of sequenced astrocytes and small cohort sizes. We developed a systems biology approach to identify astrocytic genes in public large bulk AD transcriptomes. Brain cell specific gene clusters were generated from RNA sequencing data from isolated healthy human brain cells using cell-type enr...

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Literature Corpus work: 88d8cbe5-52df-51eb-88fe-d4efedff6251
DOI: 10.1101/2021.02.25.21252422

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