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Effects of high-fat diet and CYP2B6 mutants on the pharmacokinetics of bupropion and hydroxybupropion among healthy chinese subjects

2021-01-20

Abstract excerpt

<h4>Aims: </h4> To provide evidence for the clinically rational administration of bupropion (BUP), the effects of high-fat diet and CYP2B6 mutants on BUP and hydroxybupropion (HBUP) among 44 healthy Chinese subjects. Methods The concentrations of BUP and HBUP in plasma were determined with a high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) analysis. Genotypes were ascertained after ampl...

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Literature Corpus work
8d092732-2b5b-5253-bbb9-91246913a84a
DOI
10.22541/au.161114755.51429234/v1
Open publication

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