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Article

Influence of CYP2B6 genetic variants on plasma and urine concentrations of bupropion and metabolites at steady state.

Pharmacogenetics and genomics - 1 Mar 2013

Benowitz Neal L, Zhu Andy Z X, Tyndale Rachel F, Dempsey Delia, Jacob Peyton

Abstract excerpt

BACKGROUND: Bupropion, an antidepressant and smoking cessation medication, is metabolized to hydroxybupropion (HB), an active metabolite, primarily by CYP2B6. OBJECTIVES: To compare plasma concentrations of bupropion and metabolites at steady state in healthy volunteers with and without CYP2B6 genetic variants. METHODS: In a genotype-guided study of 42 healthy individuals, we measured the plasma and urine...

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Identifiers

PMID: 23344581
DOI: 10.1097/FPC.0b013e32835d9ab0
PMCID: PMC3763712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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