Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The P450 oxidoreductase (POR) rs2868177 and cytochrome P450 (CYP) 2B6*6 polymorphisms contribute to the interindividual variability in human CYP2B6 activity.

European journal of clinical pharmacology - 1 Oct 2016

Gao Li-Chen, Liu Fang-Qun, Yang Li, Cheng Lin, Dai Hai-Ying, Tao Ran, Cao Shi-Peng, Wang Di, Tang Jie

Abstract excerpt

AIM: To investigate whether single-nucleotide polymorphisms (SNPs) in the P450 oxidoreductase (POR) gene were correlated with interindividual variations in cytochrome P450 (CYP) 2B6 activity. METHODS: Thirty-six healthy volunteers who tested CYP2B6 and POR polymorphisms were enrolled in the study. CYP2B6 activity was measured by bupropion hydroxylation with LC/MS/MS. The ratio of hydroxybupropion versus bupropion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Area Under Curve
Share to Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bupropion

Share to Cytochrome P-450 CYP2B6

Share to Cytochrome P-450 Enzyme System

Share to Healthy Volunteers

Share to Hydroxylation

Share to Young Adult

Source

Identifiers

PMID: 27439448
DOI: 10.1007/s00228-016-2095-0

Genes

POR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The P450 oxidoreductase (POR) rs2868177 and cytochrome P450 (CYP) 2B6*6 polymorphisms contribute to the interindividual variability in human CYP2B6 activity.PMID 27439448Read ↗

Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition.Semantic proximity Read ↗

Effects of Genetic Polymorphisms of CYP2B6 on the Pharmacokinetics of Bupropion and Hydroxybupropion in Healthy Chinese Subjects.Semantic proximity Read ↗

Association of CYP2B6 genetic polymorphisms with bupropion and hydroxybupropion exposure: A systematic review and meta-analysis.Semantic proximity Read ↗

Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance.Semantic proximity Read ↗

Cytochrome P450 2B6: function, genetics, and clinical relevanceSemantic proximity Read ↗

Stereoselective Bupropion Hydroxylation by Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase Genetic Variants.Semantic proximity Read ↗

Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevanceSemantic proximity Read ↗

Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes.Semantic proximity Read ↗

Influence of CYP2B6 genetic variants on plasma and urine concentrations of bupropion and metabolites at steady state.Semantic proximity Read ↗

Effect of CYP2B6*6 on Steady-State Serum Concentrations of Bupropion and Hydroxybupropion in Psychiatric Patients: A Study Based on Therapeutic Drug Monitoring Data.Semantic proximity Read ↗

Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6.Semantic proximity Read ↗

Genetic Variants of Pregnane X Receptor (PXR) and CYP2B6 Affect the Induction of Bupropion Hydroxylation by Sodium Ferulate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.