Article
Simultaneous quantification of bupropion and hydroxybupropion in human plasma by UA-DLLME-LC-MS/MS with central composite design optimization and CYP2B6 phenotyping application.
Talanta - 1 Dec 2026
Serag Ahmed, Ramzy Sherif, Alosaimi Manal E, Abduljabbar Maram H, Alaqel Saleh I, Alanazi Mashael N, Alqahtani Abdulateef, Almalki Atiah H
Abstract excerpt
A sensitive and selective LC-MS/MS bioanalytical method was developed, optimized, and validated for the simultaneous quantification of bupropion and hydroxybupropion in human plasma using ultrasound-assisted dispersive liquid-liquid microextraction (UA-DLLME) as the sample preparation technique. Four critical UA-DLLME parameters - extraction solvent volume, disperser solvent volume, sample pH, and ultrasonication...
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