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Article

Genetic Variants of Pregnane X Receptor (PXR) and CYP2B6 Affect the Induction of Bupropion Hydroxylation by Sodium Ferulate.

PloS one - 1 Jan 2013

Gao Lichen, He Yijing, Tang Jie, Yin Jiye, Huang Zhengyu, Liu Fangqun, Ouyang Dongsheng, Chen Xiaoping, Zhang Wei, Liu Zhaoqian, Zhou Honghao

Abstract excerpt

UNLABELLED: This study investigated the effects of pregnane X receptor (PXR/NR1I2) and CYP2B6 genetic variants on sodium ferulate (SF)-mediated induction of bupropion hydroxylation. The pharmacokinetics of bupropion and hydroxybupropion were evaluated after an oral dose of bupropion (150 mg) administered with and without SF pretreatment for 14 days in 33 healthy subjects. The area under the time-concentration...

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Identifiers

PMID: 23840296
DOI: 10.1371/journal.pone.0062489
PMCID: PMC3686783

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