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Article

Rapid clinical induction of bupropion hydroxylation by metamizole in healthy Chinese men.

British journal of clinical pharmacology - 1 Dec 2012

Qin Wen-Jie, Zhang Wei, Liu Zhao-Qian, Chen Xiao-Ping, Tan Zhi-Rong, Hu Dong-Li, Wang Dan, Fan Lan, Zhou Hong-Hao

Abstract excerpt

AIMS: This study aimed to investigate the effect of metamizole on bupropion hydroxylation related to different CYP2B6 genotype groups in healthy volunteers. METHODS: Sixteen healthy male volunteers (6 CYP2B6*1/*1, 6 CYP2B6*1/*6 and 4 CYP2B6*6/*6) received orally administered bupropion alone and during daily treatment with metamizole 1500 mg day(-1) (500 mg tablet taken three times daily) for 4 days. Serial blood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oxidoreductases, N-Demethylating

Source

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Identifiers

PMID: 22519658
DOI: 10.1111/j.1365-2125.2012.04304.x
PMCID: PMC3522813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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