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Article

Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition.

Clinical pharmacology and therapeutics - 1 Jan 2019

Kharasch Evan D, Crafford Amanda

Abstract excerpt

Bupropion hydroxylation is a bioactivation and metabolic pathway, and the standard clinical CYP2B6 probe. This investigation determined the influence of CYP2B6 allelic variants on clinical concentrations and metabolism of bupropion enantiomers. Secondary objectives evaluated the influence of CYP2C19 and P450 oxidoreductase variants. Healthy volunteers in specific cohorts (CYP2B6*1/*1, CYP2B6*1/*6, CYP2B6*6/*6,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2B6

Share to Cytochrome P-450 CYP2D6 Inhibitors

Share to Polymorphism, Single Nucleotide

Share to Stereoisomerism

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Source

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Identifiers

PMID: 29756345
DOI: 10.1002/cpt.1116
PMCID: PMC6927671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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