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Effect of CYP2B6*6 on Steady-State Serum Concentrations of Bupropion and Hydroxybupropion in Psychiatric Patients: A Study Based on Therapeutic Drug Monitoring Data.

Therapeutic drug monitoring - 1 Oct 2015

Høiseth Gudrun, Haslemo Tore, Uthus Linda H, Molden Espen

Abstract excerpt

BACKGROUND: The clinical effect of bupropion is mediated by its active metabolite hydroxybupropion. Previous studies have reported conflicting impact of the CYP2B6*6 variant allele on the formation of hydroxybupropion from bupropion. The aim of this study was to clarify the effect of CYP2B6*6 and secondarily CYP2D6 genotype on steady-state serum concentrations of bupropion and hydroxybupropion in a large...

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PMID: 25565674
DOI: 10.1097/FTD.0000000000000183

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