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Article

Association of CYP2B6 genetic polymorphisms with bupropion and hydroxybupropion exposure: A systematic review and meta-analysis.

Pharmacotherapy - 1 Jan 2022

Eum Seenae, Sayre Franklin, Lee Adam M, Stingl Julia C, Bishop Jeffrey R

Abstract excerpt

INTRODUCTION: Bupropion is metabolized to its active metabolite, hydroxybupropion (HB), by the genetically polymorphic cytochrome P450 2B6 (CYP2B6) enzyme. Despite its significant role in bupropion metabolism, the magnitude of the impact of CYP2B6 genotype on the exposure of bupropion has not been quantified. OBJECTIVES: A systematic review and meta-analysis was conducted to quantify the association of bupropion...

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PMID: 34752647
DOI: 10.1002/phar.2644

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