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Article

Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2011

Chung Jae Yong, Cho Joo-Youn, Lim Hyeong-Seok, Kim Jung-Ryul, Yu Kyung-Sang, Lim Kyoung Soo, Shin Sang-Goo, Jang In-Jin

Abstract excerpt

We investigated genetic polymorphisms in the pregnane X receptor (NR1I2) in Korean individuals (n = 83) and the effects of NR1I2 genotypes on rifampin-mediated induction of bupropion hydroxylation. The pharmacokinetics of bupropion and hydroxybupropion were evaluated after an oral dose of bupropi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oxidoreductases, N-Demethylating

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Source

Identifiers

PMID: 20876786
DOI: 10.1124/dmd.110.035246

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20876786-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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