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Article

Effects of Genetic Polymorphisms of CYP2B6 on the Pharmacokinetics of Bupropion and Hydroxybupropion in Healthy Chinese Subjects.

Medical science monitor : international medical journal of experimental and clinical research - 11 Apr 2018

Ma Hui, Zhang Wenping, Yang Xiaoying, Zhang Yuxin, Wei Shijie, Zhang Hao, Ma Yanni, Dang Hongwan

Abstract excerpt

BACKGROUND Bupropion (BUP) is an antidepressant and its pharmacological activity is mediated by its major metabolite, hydroxybupropion (HBUP). We investigated the effects of genetic polymorphisms of CYP2B6 on BUP and HBUP to provide certain evidence on the clinical rational administration of BUP. MATERIAL AND METHODS Plasma BUP and HBUP concentrations were assayed using high performance liquid...

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Identifiers

PMID: 29637923
DOI: 10.12659/msm.909227
PMCID: PMC5914277

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