Article

The Pick fold in tau filaments from human <i>MAPT</i> mutants

2026-03-09

Abstract excerpt

Mutations in MAPT , the tau gene, give rise to forms of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17T), with abundant filamentous tau inclusions in brain cells. Some mutations that encode missense and deletion variants can give rise to a clinical picture of Pick’s disease and filaments made of three-repeat tau. Here we report the electron cryo-microscopy (cryo-EM) structures of tau fi...

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Literature Corpus work: 8cea5158-dc70-59ef-8b04-b06e91f1256d
DOI: 10.64898/2026.03.08.710379

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