Article
The Pick fold in tau filaments from human MAPT mutants.
Acta neuropathologica - 8 Jul 2026
Qi Chao, Lövestam Sofia, Shi Jenny, Murzin Alexey G, Peak-Chew Sew, Warner Thomas T, Seelaar Harro, Cullinane Patrick W, Jaunmuktane Zane, van Swieten John C, Scheres Sjors H W, Goedert Michel
Abstract excerpt
Mutations in MAPT, the tau gene, give rise to forms of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17 T), with abundant filamentous tau inclusions in brain cells. Some mutations that encode missense and deletion variants can give rise to a clinical picture of Pick's disease and filaments made of three-repeat tau in nerve cells. Here we report the electron cryo-microscopy (cryo-EM)...
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