Article

Structures of filaments from Pick’s disease reveal a novel tau protein fold

2018-04-16

Abstract excerpt

The ordered assembly of tau protein into abnormal filamentous inclusions underlies many human neurodegenerative diseases 1 . Tau assemblies appear to spread through specific neural networks in each disease 2 , with short filaments having the greatest seeding activity 3 . The abundance of tau inclusions strongly correlates with disease symptoms 4 . Six tau isoforms are expressed in normal adult human brain - th...

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Identifiers and source

Literature Corpus work: 27f2e594-9c04-598e-bb64-184c31802768
DOI: 10.1101/302216

Open publication

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