Reconstitution of the Alzheimer’s Disease Tau Core Structure from Recombinant Tau 297–391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide The protein tau misfolds into disease-specific fibrillar structures in more than 20 neurodegenerative diseases collectively referred to as tauopathies. To understand and prevent disease-specific mechanisms of filament formation, in vitro models for aggregation that robustly yield these different end point structures will be necessary. Here, we used cryo-electron...

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