Article
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W.
Nature structural & molecular biology - 1 Jul 2025
Qi Chao, Lövestam Sofia, Murzin Alexey G, Peak-Chew Sew, Franco Catarina, Bogdani Marika, Latimer Caitlin, Murrell Jill R, Cullinane Patrick W, Jaunmuktane Zane, Bird Thomas D, Ghetti Bernardino, Scheres Sjors H W, Goedert Michel
Abstract excerpt
Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are the most common forms of early-onset dementia. Unlike AD, FTD begins with behavioral changes before the development of cognitive impairment. Dominantly inherited mutations in MAPT, the microtubule-associated protein tau gene, give rise to cases of FTD and parkinsonism linked to chromosome 17. These individuals develop abundant filamentous tau...
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