Article

Novel tau filament folds in individuals with <i>MAPT</i> mutations P301L and P301T

2024-08-17

Abstract excerpt

Mutations in MAPT , the microtubule-associated protein tau gene, give rise to cases of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) with abundant filamentous tau inclusions in brain cells. Individuals with pathological MAPT variants exhibit behavioural changes, cognitive impairment and signs of parkinsonism. Missense mutations of residue P301, which are the most common MAPT mutatio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 76c54646-6899-5f8b-b794-092451cb3a6b
DOI: 10.1101/2024.08.15.608062

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel tau filament folds in individuals with <i>MAPT</i> mutations P301L and P301TDOI 10.1101/2024.08.15.608062Read

Distinct tau filament folds in human MAPT mutants P301L and P301T.Semantic proximity Read

The Pick fold in tau filaments from human <i>MAPT</i> mutantsSemantic proximity Read

Tau filaments with the Alzheimer fold in cases with <i>MAPT</i> mutations V337M and R406WSemantic proximity Read

The Pick fold in tau filaments from human MAPT mutants.Semantic proximity Read

Distinct tau filament folds in familial frontotemporal dementia due to the <i>MAPT</i> S305I mutationSemantic proximity Read

Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W.Semantic proximity Read

Tau filaments in neurodegenerative diseasesSemantic proximity Read

Structure-based classification of tauopathies.Semantic proximity Read

Structure-based Classification of TauopathiesSemantic proximity Read

Tau and neurodegeneration.Semantic proximity Read

Structures of filaments from Pick’s disease reveal a novel tau protein foldSemantic proximity Read

Phenotypic heterogeneity within a new family with the MAPT p301s mutation.Semantic proximity Read