Article
Structure-based classification of tauopathies.
Nature - 1 Oct 2021
Shi Yang, Zhang Wenjuan, Yang Yang, Murzin Alexey G, Falcon Benjamin, Kotecha Abhay, van Beers Mike, Tarutani Airi, Kametani Fuyuki, Garringer Holly J, Vidal Ruben, Hallinan Grace I, Lashley Tammaryn, Saito Yuko, Murayama Shigeo, Yoshida Mari, Tanaka Hidetomo, Kakita Akiyoshi, Ikeuchi Takeshi, Robinson Andrew C, Mann David M A, Kovacs Gabor G, Revesz Tamas, Ghetti Bernardino, Hasegawa Masato, Goedert Michel, Scheres Sjors H W
Abstract excerpt
The ordered assembly of tau protein into filaments characterizes several neurodegenerative diseases, which are called tauopathies. It was previously reported that, by cryo-electron microscopy, the structures of tau filaments from Alzheimer's disease1,2, Pick's disease3, chronic traumatic encephalopathy4 and corticobasal degeneration5 are distinct. Here we show that the structures of tau filaments from...
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