Article

Novel tau filament fold in corticobasal degeneration, a four-repeat tauopathy

2019-10-21

Abstract excerpt

Corticobasal degeneration (CBD) is a neurodegenerative tauopathy that is characterised by motor and cognitive disturbances (1–3). A higher frequency of the H1 haplotype of MAPT , the tau gene, is present in cases of CBD than in controls (4, 5) and genome-wide association studies have identified additional risk factors (6). By histology, astrocytic plaques are diagnostic of CBD (7, 8), as are detergent-insoluble...

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Literature Corpus work: 64426cbf-84c2-5863-8616-6404424595f8
DOI: 10.1101/811703

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