Article

Tau filaments with the Alzheimer fold in cases with <i>MAPT</i> mutations V337M and R406W

2024-04-30

Abstract excerpt

Frontotemporal dementia (FTD) and Alzheimer’s disease are the most common forms of early-onset dementia. Dominantly inherited mutations in MAPT , the microtubule-associated protein tau gene, cause FTD and parkinsonism linked to chromosome 17 (FTDP-17). Individuals with FTDP-17 develop abundant filamentous tau inclusions in brain cells. Here we used electron cryo-microscopy to determine the structures of tau filam...

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Literature Corpus work: 6ffd08da-db03-5c7a-8138-8e6e28ab6610
DOI: 10.1101/2024.04.29.591661

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