Article
Distinct tau filament folds in human MAPT mutants P301L and P301T.
Nature structural & molecular biology - 1 Aug 2025
Schweighauser Manuel, Shi Yang, Murzin Alexey G, Garringer Holly J, Vidal Ruben, Murrell Jill R, Erro M Elena, Seelaar Harro, Ferrer Isidro, van Swieten John C, Ghetti Bernardino, Scheres Sjors H W, Goedert Michel
Abstract excerpt
Mutations in MAPT, the tau gene, give rise to frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), with abundant filamentous tau inclusions in brain cells. Mutations that encode missense variants of residue P301 are the most common and result in the formation of filamentous inclusions made of mutant four-repeat tau. Here we report the cryo-electron microscopy structures of tau filaments...
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